Healthspan Optimization

Rapamycin is one of the most exciting longevity drugs in development. Originally used in organ transplant medicine, it’s now being studied for its role in mTOR inhibition—a pathway deeply involved in cellular aging.

In animal studies, rapamycin has extended lifespan by over 30% (Miller et al., 2011). It works by mimicking the effects of caloric restriction, reducing cellular senescence, and enhancing autophagy. At Compass, we offer intermittent dosing protocols designed to minimize risks while enhancing anti-aging benefits.

Our clinical team evaluates each candidate for rapamycin therapy using biomarkers, patient goals, and metabolic context. Dosing is typically once weekly to avoid side effects associated with chronic suppression of immune function. We monitor inflammatory markers, white blood cell counts, and glucose metabolism to keep everything in balance.

Rapamycin is offered under physician supervision and is paired with lifestyle protocols designed to maximize its benefits—like strength training, time-restricted eating, and mitochondrial support. We also provide pharmaceutical-grade formulations and precision dosing based on your tolerance and lab response.

Metformin, traditionally used for Type 2 diabetes, is gaining serious attention in the longevity world. It improves insulin sensitivity, reduces oxidative stress, and has been linked to lower cancer risk in epidemiological studies (Barzilai et al., 2016).

We use metformin off-label in metabolically healthy individuals with careful monitoring—especially for those with elevated insulin, visceral fat, or inflammation markers. Our protocols are tailored to minimize any interference with exercise-induced adaptations or muscle hypertrophy.

At L2, metformin is typically introduced at low doses and titrated gradually.

We offer:

• Extended-release formulations for better gastrointestinal tolerance
• Routine testing of fasting insulin, HOMA-IR, and vitamin B12 levels
• Stacking protocols that combine metformin with lifestyle changes, nutraceuticals, and occasional cycling off

Metformin’s benefits go beyond glucose regulation. It supports mitochondrial function, improves endothelial health, and may help reduce the accumulation of senescent cells. In short: it’s a metabolic multitool—and we help you wield it wisely.

NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every cell of your body, critical for mitochondrial energy production, DNA repair, and healthy aging. But NAD levels decline rapidly with age, contributing to fatigue, inflammation, metabolic dysfunction, and cognitive decline.

Optimizing NAD helps improve endurance, brain performance, metabolic resilience, and recovery. We track your progress through functional testing and offer flexible options for in-clinic IVs, take-home stacks, or a hybrid plan that fits your lifestyle. At L2, we offer NAD support through:

• IV infusions
• Oral NAD+ precursors like NR or NMN
• Mitochondrial support stacks to enhance absorption and efficacy

The result? Better focus, more energy, and cellular regeneration from the inside out.

At L2, we offer a comprehensive NAD optimization strategy using multiple modalities:

• IV NAD+ Therapy: Delivered directly into your bloodstream for immediate availability. Our NAD infusions typically run over 1–2 hours in a comfortable setting and can be customized based on your tolerance and goals. Patients report enhanced mental clarity, reduced brain fog, improved mood, and increased stamina.
• Oral NAD Precursors: We use high-quality, pharmaceutical-grade nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN) supplements to support daily mitochondrial health. These are ideal for maintenance between IV sessions.
• Mitochondrial Support Stacks: We combine NAD therapy with co-factors like resveratrol, PQQ, and CoQ10 to enhance absorption, reduce inflammation, and promote sustained cellular energy.

No healthspan strategy is complete without optimizing the foundations of human performance. At L2, we integrate advanced biomarker testing with personalized coaching to improve the three most essential lifestyle pillars: movement, rest, and repair.

Exercise: We design movement protocols tailored to your VO₂ max, muscle mass, joint health, and goals. Whether you’re training for longevity, hypertrophy, or resilience, we optimize:

• Aerobic conditioning for mitochondrial health
• Resistance training to prevent sarcopenia and insulin resistance
• Mobility and functional performance to reduce injury risk

Sleep: Deep, restorative sleep is a non-negotiable requirement for cellular repair, hormonal balance, and brain health. At L2, we assess:

• Circadian rhythm alignment (photobiomodulation)
• Sleep staging and quality (via Oura or Whoop)
• Melatonin, cortisol, and HRV trends

We create personalized strategies that include nutritional timing, light therapy, supplementation, and behavioral guidance to deepen your recovery cycles.

Recovery: Recovery isn’t just about rest—it’s about actively rebalancing your nervous system and inflammation levels. We incorporate:

• HRV-guided stress management
• Nutraceutical support for adrenal and mitochondrial recovery
• Breathwork, cold therapy, and mobility-based interventions
• Energy based medicines like shockwave and photobiomodulation (red-light therapy)

These foundational pillars work synergistically with our clinical therapies to keep you high-performing and biologically younger—year after year.